Numerical modelling of label-structured cell population growth using CFSE distribution data
نویسندگان
چکیده
منابع مشابه
Quantifying cell turnover using CFSE data.
The CFSE dye dilution assay is widely used to determine the number of divisions a given CFSE labelled cell has undergone in vitro and in vivo. In this paper, we consider how the data obtained with the use of CFSE (CFSE data) can be used to estimate the parameters determining cell division and death. For a homogeneous cell population (i.e., a population with the parameters for cell division and ...
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Centile values and growth charts for height, weight and arm circumference are presented for school children aged six to 12 years in Shiraz (Iran). The smooth centile values have been derived from the raw data by Healy's nonparametric method. Girls grow faster than boys. Homogeneity of data with population structure and universal rationing imply that these norms are likely to be appropriate...
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Advances in fluorescent labeling of cells as measured by flow cytometry have allowed for quantitative studies of proliferating populations of cells. The investigations (Luzyanina et al. in J. Math. Biol. 54:57-89, 2007; J. Math. Biol., 2009; Theor. Biol. Med. Model. 4:1-26, 2007) contain a mathematical model with fluorescence intensity as a structure variable to describe the evolution in time o...
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We developed a series of models for the label decay in cell proliferation assays when the intracellular dye carboxyfluorescein succinimidyl ester (CFSE) is used as a staining agent. Data collected from two healthy patients were used to validate the models and to compare the models with the Akiake Information Criteria. The distinguishing features of multiple decay rates in the data are readily c...
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We present a general class of cell population models that can be used to track the proliferation of cells which have been labeled with a fluorescent dye. The mathematical models employ fluorescence intensity as a structure variable to describe the evolution in time of the population density of proliferating cells. While cell division is a major component of changes in cellular fluorescence inte...
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ژورنال
عنوان ژورنال: Theoretical Biology and Medical Modelling
سال: 2007
ISSN: 1742-4682
DOI: 10.1186/1742-4682-4-26